CD18-mediated neutrophil recruitment contributes to the pathogenesis of reperfused but not nonreperfused stroke Academic Article uri icon

Overview

MeSH Major

  • Antigens, CD18
  • Brain Ischemia
  • Cerebrovascular Disorders
  • Neutrophils
  • Reperfusion Injury

abstract

  • Deficiency for the CD18 gene confers cerebral protection in a murine model of reperfused stroke, but this benefit does not extend to CD18-deficient animals subjected to permanent MCA occlusion. These data suggest that anti-PMN strategies should be targeted to reperfused stroke and may perhaps be used in conjunction with thrombolytic therapy that establishes reperfusion.

publication date

  • May 1999

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10229752

Additional Document Info

start page

  • 1110

end page

  • 7

volume

  • 30

number

  • 5