An overview of tumor necrosis factor α and the failing human heart Article Report uri icon

Overview

MeSH Major

  • Heart Failure
  • Inflammation Mediators
  • Interleukin-6
  • Tumor Necrosis Factor-alpha

abstract

  • Recent studies have identified the importance of biologically active molecules (e.g., neurohormones) in disease progression in heart failure. In addition to neurohormones, another portfolio of biologically active molecules, termed cytokines, are also expressed in the setting of heart failure. This article reviews recent clinical and experimental material that suggest that the cytokines (e.g., tumor necrosis factor alpha), much like the neurohormones, may represent another class of biologically active molecules that are responsible for the development and progression of heart failure.

publication date

  • May 7, 1999

Research

keywords

  • Report

Identity

Digital Object Identifier (DOI)

  • 10.1097/00001573-199905000-00003

PubMed ID

  • 10358791

Additional Document Info

start page

  • 206

end page

  • 10

volume

  • 14

number

  • 3