Expression of c-fos, c-jun, and c-jun N-terminal kinase (JNK) in a developmental model of induced apoptotic death in neurons of the substantia nigra. Academic Article uri icon

Overview

MeSH

  • Animals
  • Dopamine
  • Female
  • MAP Kinase Kinase 4
  • Nerve Degeneration
  • Neurotoxins
  • Parkinson Disease
  • Pregnancy
  • Quinolinic Acid
  • Rats
  • Substantia Nigra

MeSH Major

  • Apoptosis
  • JNK Mitogen-Activated Protein Kinases
  • Mitogen-Activated Protein Kinase Kinases
  • Neurons
  • Protein Kinases
  • Proto-Oncogene Proteins c-fos
  • Proto-Oncogene Proteins c-jun

abstract

  • The transcription factors c-fos and c-jun have been proposed to play a role in the initiation of programmed cell death in neurons. We have shown that programmed cell death, with the morphology of apoptosis, occurs in dopamine neurons of the substantia nigra (SN) during normal postnatal development and that this death event can be induced by early striatal target injury. We have investigated the relationship between c-fos and c-jun protein expression and induced death in neurons of the SN. Although c-fos is induced, it is unlikely to play a role in cell death, because its expression is not well correlated with apoptotic death either temporally or at a cellular level. Expression of c-jun, however, is both temporally and regionally correlated with induction of death, and, at a cellular level, it colocalizes with apoptotic morphology. The increased expression of c-jun is likely to be functionally significant, because it is associated with increased c-jun N-terminal kinase (JNK) and phosphorylated c-jun expression. JNK expression also colocalizes with apoptotic morphology. We conclude that c-jun is likely to play a role in the initiation of apoptotic cell death in these neurons.

publication date

  • February 1999

has subject area

  • Animals
  • Apoptosis
  • Dopamine
  • Female
  • JNK Mitogen-Activated Protein Kinases
  • MAP Kinase Kinase 4
  • Mitogen-Activated Protein Kinase Kinases
  • Nerve Degeneration
  • Neurons
  • Neurotoxins
  • Parkinson Disease
  • Pregnancy
  • Protein Kinases
  • Proto-Oncogene Proteins c-fos
  • Proto-Oncogene Proteins c-jun
  • Quinolinic Acid
  • Rats
  • Substantia Nigra

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed ID

  • 9930727

Additional Document Info

start page

  • 557

end page

  • 564

volume

  • 72

number

  • 2