Expression of HER2/erbB-2 correlates with survival in osteosarcoma Academic Article uri icon

Overview

MeSH Major

  • Bone Neoplasms
  • Neoplasm Proteins
  • Osteosarcoma
  • Receptor, ErbB-2

abstract

  • The correlation of HER2/erbB-2 expression with histologic response to preoperative chemotherapy and event-free survival in this study suggests that HER2/erbB-2 should be evaluated prospectively as a prognostic indicator. The correlation also suggests that clinical trials of antibodies that target this receptor, such as recombinant humanized anti-HER2 monoclonal antibody (Herceptin; Genentech, San Francisco, CA), should be considered for the treatment of osteosarcoma.

publication date

  • September 1999

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10561353

Additional Document Info

start page

  • 2781

end page

  • 8

volume

  • 17

number

  • 9