Can p53 help select patients with invasive bladder cancer for bladder preservation?
Antineoplastic Combined Chemotherapy Protocols
Urinary Bladder Neoplasms
Our study suggests that the bladder may be preserved for up to 10 years in patients with tumors confined to the bladder (stage T2) who lack detectable p53 if they respond completely to neoadjuvant chemotherapy. Patients with T3 bladder tumors or T2 p53 positive tumors are best treated currently with cystectomy.