Sonic hedgehog regulates the growth and patterning of the cerebellum Academic Article uri icon

Overview

MeSH Major

  • Body Patterning
  • Cerebellum
  • Nerve Tissue Proteins
  • Neurons
  • Proteins
  • Repressor Proteins
  • Trans-Activators
  • Xenopus Proteins

abstract

  • The molecular bases of brain development and CNS malignancies remain poorly understood. Here we show that Sonic hedgehog (Shh) signaling controls the development of the cerebellum at multiple levels. SHH is produced by Purkinje neurons, it is required for the proliferation of granule neuron precursors and it induces the differentiation of Bergmann glia. Blocking SHH function in vivo results in deficient granule neuron and Bergmann glia differentiation as well as in abnormal Purkinje neuron development. Thus, our findings provide a molecular model for the growth and patterning of the cerebellum by SHH through the coordination of the development of cortical cerebellar cell types. In addition, they provide a cellular context for medulloblastomas, childhood cancers of the cerebellum.

publication date

  • July 1999

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10375501

Additional Document Info

start page

  • 3089

end page

  • 100

volume

  • 126

number

  • 14