Expression of aberrantly spliced oncogenic Ikaros isoforms in childhood acute lymphoblastic leukemia Academic Article uri icon

Overview

MeSH Major

  • Alternative Splicing
  • DNA-Binding Proteins
  • Gene Expression Regulation, Neoplastic
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Transcription Factors

abstract

  • Our findings link specific molecular defects involving the Ikaros gene to childhood ALL. Posttranscriptional regulation of alternative splicing of Ikaros RNA seems to be defective in leukemic lymphocyte precursors from most children with ALL. Consequently, leukemic cells from ALL patients, in contrast to normal lymphocyte precursors, express high levels of non-DNA-binding Ikaros isoforms that are reminiscent of the non-DNA-binding Ikaros isoforms that lead to lymphoblastic leukemia in mice.

publication date

  • December 1999

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10577847

Additional Document Info

start page

  • 3753

end page

  • 66

volume

  • 17

number

  • 12