Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor α Academic Article uri icon

Overview

MeSH Major

  • Homeodomain Proteins
  • Islets of Langerhans
  • Pancreatic Ducts
  • Trans-Activators
  • Tumor Necrosis Factor-alpha

abstract

  • Overexpression of TGF-alpha induces expansion of a Pdx1-expressing epithelium characterized by focal expression of Pax6 and initiation of islet neogenesis. These findings suggest that premalignant events induced by TGF-alpha in mouse pancreas may recapitulate a developmental program active during embryogenesis.

publication date

  • January 1999

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10579983

Additional Document Info

start page

  • 1416

end page

  • 26

volume

  • 117

number

  • 6