Bcl-x(L) and Bcl-2 expression in squamous cell carcinoma of the head and neck Academic Article Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Lung Neoplasms
  • Small Cell Lung Carcinoma

abstract

  • These results suggest that disruption of apoptotic control pathways is an important event in the evolution of squamous cell carcinoma of the head and neck. A common mechanism for this disruption involves overexpression of Bcl-xL, Patients whose tumors demonstrate Bcl-2 positivity, even with locoregionally advanced disease, appear to have a high likelihood of cure with aggressive combined modality therapy and may be treated successfully with less toxic therapy.

publication date

  • January 1999

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/(SICI)1097-0142(19990101)85:1<164::AID-CNCR23>3.0.CO;2-Q

PubMed ID

  • 9921989

Additional Document Info

start page

  • 164

end page

  • 70

volume

  • 85

number

  • 1