Kinetic modeling of [99mTc]TRODAT- 1: A dopamine transporter imaging agent
Academic Article
Overview
MeSH Major
Brain
Carrier Proteins
Dopamine
Membrane Glycoproteins
Membrane Transport Proteins
Nerve Tissue Proteins
Organotechnetium Compounds
Tropanes
abstract
These findings suggest that the binding potential and corresponding kinetic rate constants can be reliably estimated in nonhuman primates with dynamic SPECT imaging of the dopamine transporter using a technetium-based tropane analogue. Furthermore, method II parameter vectors compare favorably to those produced using method I based on SEEs.
