Transdermal nitroglycerin patch therapy improves left ventricular function and prevents remodeling after acute myocardial infarction: Results of a multicenter prospective randomized, double-blind, placebo-controlled trial
Ventricular Function, Left
Transdermal NTG patches prevent LV dilation in patients surviving AMI. The beneficial effects are limited to patients with depressed LV function and only at the lowest (0.4-mg/h) dose. Continued administration is necessary to maintain efficacy. Whether these remodeling effects confer a clinical or survival advantage will need to be addressed in an adequately powered cardiac event trial.