Long-term adrenalectomy decreases NMDA receptors in rat hippocampus Academic Article uri icon

Overview

MeSH Major

  • Adrenal Glands
  • Adrenalectomy
  • Hippocampus
  • Receptors, N-Methyl-D-Aspartate

abstract

  • The effect of long-term adrenalectomy on NMDA receptors in the rat hippocampus was studied. Hippocampal sections of control and adrenalectomized rats were incubated with [3H]MK-801, a radiolabeled non-competitive inhibitor of the NMDA receptor. Analysis by in vitro autoradiography showed a significant decrease in [3H]MK-801 binding in the dentate gyrus, CA1 and CA4 areas, as well as the temporal cortex. Results of this study suggest that glucocorticoids are vital for the regulation of the NMDA receptors.

publication date

  • June 22, 1998

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 9674584

Additional Document Info

start page

  • 2011

end page

  • 4

volume

  • 9

number

  • 9