Use of the percentage of free prostate-specific antigen to enhance differentiation of prostate cancer from benign prostatic disease: A prospective multicenter clinical trial Academic Article Article uri icon


MeSH Major

  • Urologic Diseases
  • Urology


  • Use of the percentage of free PSA can reduce unnecessary biopsies in patients undergoing evaluation for prostate cancer, with a minimal loss in sensitivity in detecting cancer. A cutoff of 25% or less free PSA is recommended for patients with PSA values between 4.0 and 10.0 ng/mL and a palpably benign gland, regardless of patient age or prostate size. To our knowledge, this study is the largest series to date evaluating the percentage of free PSA in a population representative of patients in whom the test would be used in clinical practice.

publication date

  • May 20, 1998



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1001/jama.279.19.1542

PubMed ID

  • 9605898

Additional Document Info

start page

  • 1542

end page

  • 7


  • 279


  • 19