Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development Academic Article Article uri icon


MeSH Major

  • Societies, Scientific


  • The leukocyte-specific adapter molecule SLP-76 (Src homology 2 domain-containing leukocyte protein of 76 kilodaltons) is rapidly phosphorylated on tyrosine residues after receptor ligation in several hematopoietically derived cell types. Mice made deficient for SLP-76 expression contained no peripheral T cells as a result of an early block in thymopoiesis. Macrophage and natural killer cell compartments were intact in SLP-76-deficient mice, despite SLP-76 expression in these lineages in wild-type mice. Thus, the SLP-76 adapter protein is required for normal thymocyte development and plays a crucial role in translating signals mediated by pre-T cell receptors into distal biochemical events.

publication date

  • July 17, 1998



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1126/science.281.5375.416

PubMed ID

  • 9665885

Additional Document Info

start page

  • 416

end page

  • 9


  • 281


  • 5375