A Bcl-x(L) transgene promotes malignant conversion of chemically initiated skin papillomas Academic Article uri icon

Overview

MeSH Major

  • Papilloma
  • Proto-Oncogene Proteins c-bcl-2
  • Skin Neoplasms

abstract

  • The role of apoptosis in the pathogenesis of skin cancer was analyzed in mice bearing a Bcl-xL transgene expressed under the control of the keratin 14 promoter. No spontaneous tumors developed in the skin of these transgenic mice. Bcl-xL transgenics also failed to develop skin lesions following treatment with the chemical mutagen 9,10-dimethyl-1,2-benzanthracene, or the tumor promoter O-tetradecanoylphorbol-13-acetate. However, Bcl-xL transgenics developed a two-fold greater number of benign papillomas than control littermates following treatment with the combination of 9,10-dimethyl-1,2-benzanthracene and O-tetradecanoylphorbol-13-acetate. More significantly, Bcl-xL transgenic mice developed invasive squamous cell carcinoma earlier and more frequently than wild-type controls in response to the chemical agents. These data suggest that Bcl-xL cannot functionally substitute for a mutagenic initiator or mitogenic promoter in tumorigenesis. In contrast, Bcl-xL overexpression can dramatically increase the malignant conversion rate of benign tumors, suggesting that inhibition of apoptosis can contribute to tumor progression.

publication date

  • May 15, 1998

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 9605754

Additional Document Info

start page

  • 2111

end page

  • 6

volume

  • 58

number

  • 10