Class restriction of cephalosporin use to control total cephalosporin resistance in nosocomial Klebsiella
Drug Resistance, Multiple, Bacterial
Escherichia coli Infections
Extensive cephalosporin class restriction significantly reduced nosocomial, plasmid-mediated, cephalosporin-resistant Klebsiella infection and colonization. This occurred at the price of increased imipenem resistance in P aeruginosa, which remained susceptible to other agents. Thus, an overall reduction in multiply-resistant pathogens was achieved within 1 year.