Interim analysis of the incidence of breast cancer in the Royal Marsden Hospital tamoxifen randomised chemoprevention trial Academic Article Article uri icon


MeSH Major

  • Breast Neoplasms
  • Gene Transfer Techniques
  • Genetic Therapy


  • We have been unable to show any effect of tamoxifen on breast-cancer incidence in healthy women, contrary to the report from the NSABP-P1 study showing a 45% reduction in healthy women given tamoxifen versus placebo. Differences in the study populations for the two trials may underlie these conflicting findings: eligibility in our trial was based predominantly on a strong family history of breast cancer whereas in the NSABP trial was mostly based on non-genetic risk factors. The importance of oestrogen promotion may vary between such populations.

publication date

  • July 11, 1998



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/S0140-6736(98)85012-5

PubMed ID

  • 9672274

Additional Document Info

start page

  • 98

end page

  • 101


  • 352


  • 9122