Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice Article Conference Paper uri icon

Overview

MeSH Major

  • DNA, Viral
  • Plants
  • RNA Viruses
  • RNA-Directed DNA Polymerase

abstract

  • Basic fibroblast growth factor (bFGF) is overexpressed in most high-grade human gliomas, implying that it is involved in the pathogenesis of these tumors. To assess the biological effect of inappropriate production of bFGF in normal astrocytes, we developed a system for glia-specific gene transfer in transgenic mice. A transgene encoding the receptor for subgroup A avian leukosis virus and controlled by the astrocyte-specific glial fibrillary acidic protein promoter permits efficient glia-specific transfer of genes carried by subgroup A avian leukosis virus vectors. With this system, we have demonstrated that bFGF induces proliferation and migration of glial cells in vivo, without the induction of tumors.

publication date

  • February 3, 1998

Research

keywords

  • Conference Paper

Identity

Digital Object Identifier (DOI)

  • 10.1073/pnas.95.3.1218

PubMed ID

  • 9448312

Additional Document Info

start page

  • 1218

end page

  • 23

volume

  • 95

number

  • 3