Predictors of response to acute treatment of chronic and double depression with sertraline or imipramine
Antidepressive Agents, Tricyclic
Serotonin Uptake Inhibitors
A higher baseline quality of life, living with spouse or partner, and having more education were the strongest predictors of response to acute pharmacotherapy among chronically depressed patients. Clinical variables and comorbidity were not identified as independent predictors, although personality traits did appear to influence treatment response. Overall, the predictive value of these baseline measures was modest, and therefore of limited clinical utility.