Molecular abnormalities in myeloid leukemias and myelodysplastic syndromes Article Report uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Drug Resistance, Neoplasm
  • Models, Theoretical
  • Neoplasms

abstract

  • Analysis of chromosome translocations in human myeloid leukemias and myelodysplastic syndromes has identified a number of genes involved in the pathogenesis of these diseases. Most of the genes identified to date can be grouped into one of three major classes--transcription factors, tyrosine kinases or nuclear pore proteins. Recent insights into the molecular basis of these leukemias is presented using selected examples from these groups.

publication date

  • December 1998

Research

keywords

  • Report

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0145-2126(98)00109-X

PubMed ID

  • 9922075

Additional Document Info

start page

  • 1113

end page

  • 22

volume

  • 22

number

  • 12