A novel signaling pathway from rod photoreceptors to ganglion cells in mammalian retina Academic Article Article uri icon

Overview

MeSH Major

  • Color Vision
  • Color Vision Defects
  • Genetic Therapy
  • Light
  • Optogenetics
  • Retinal Cone Photoreceptor Cells
  • Retinal Degeneration

abstract

  • Current understanding suggests that mammalian rod photoreceptors connect only to an ON-type bipolar cell. This rod-specific bipolar cell excites the All amacrine cell, which makes connections to cone-specific bipolar cells of both ON and OFF type; these, in turn, synapse with ganglion cells. Recent work on rabbit retina has shown that rod signals can also reach ganglion cells without passing through the rod bipolar cell. This route was thought to be provided by electrical gap junctions, through which rods signal directly to cones and thence to cone bipolar cells. Here, we show that the mouse retina also provides a rod pathway bypassing the rod bipolar cell, suggesting that this is a common feature in mammals. However, this alternative pathway does not require cone photoreceptors; it is perfectly intact in a transgenic mouse whose retina lacks cones. Instead, the results can be explained if rods connect directly to OFF bipolar cells.

publication date

  • September 1998

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0896-6273(00)80560-7

PubMed ID

  • 9768836

Additional Document Info

start page

  • 481

end page

  • 93

volume

  • 21

number

  • 3