Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats Academic Article uri icon

Overview

MeSH Major

  • Cytological Techniques
  • Mesencephalon
  • Parkinson Disease, Secondary
  • Stem Cell Transplantation

abstract

  • In vitro expansion of central nervous system (CNS) precursors might overcome the limited availability of dopaminergic neurons in transplantation for Parkinson's disease, but generating dopaminergic neurons from in vitro dividing precursors has proven difficult. Here a three-dimensional cell differentiation system was used to convert precursor cells derived from E12 rat ventral mesencephalon into dopaminergic neurons. We demonstrate that CNS precursor cell populations expanded in vitro can efficiently differentiate into dopaminergic neurons, survive intrastriatal transplantation and induce functional recovery in hemiparkinsonian rats. The numerical expansion of primary CNS precursor cells is a new approach that could improve both the ethical and the technical outlook for the use of human fetal tissue in clinical transplantation.

publication date

  • December 1998

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10195162

Additional Document Info

start page

  • 290

end page

  • 5

volume

  • 1

number

  • 4