Ku70: A candidate tumor suppressor gene for murine T cell lymphoma Academic Article uri icon

Overview

MeSH Major

  • Antigens, Nuclear
  • DNA Helicases
  • DNA-Binding Proteins
  • Genes, Tumor Suppressor
  • Lymphoma, T-Cell
  • Nuclear Proteins
  • Protein-Serine-Threonine Kinases

abstract

  • We present evidence that inactivation of the Ku70 gene leads to a propensity for malignant transformation both in vitro and in vivo. In vitro, Ku70-/- mouse fibroblasts displayed an increased rate of sister chromatid exchange and a high frequency of spontaneous neoplastic transformation. In vivo, Ku70-/- mice, known to be defective in B but not T lymphocyte maturation, developed thymic and disseminated T cell lymphomas at a mean age of 6 months with CD4+CD8+ tumor cells. These findings directly demonstrate that Ku70 deficiency facilitates neoplastic growth and suggest a novel role of the Ku70 locus in tumor suppression.

publication date

  • July 1998

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 9702186

Additional Document Info

start page

  • 1

end page

  • 8

volume

  • 2

number

  • 1