Teratoma with malignant transformation: Diverse malignant histologies arising in men with germ cell tumors Academic Article uri icon

Overview

MeSH Major

  • Cell Transformation, Neoplastic
  • Germinoma
  • Teratoma
  • Testicular Neoplasms

abstract

  • A variety of nongerm cell histologies, including sarcoma, adenocarcinoma, primitive neuroectodermal tumor and leukemia, may occur in association with germ cell tumor. Chromosomal abnormalities in these tumors include i (12p), reflecting germ cell tumor clonality, as well as chromosomal abnormalities associated with the transformed histology. These tumors do not respond like germ cell tumor to cisplatin-containing chemotherapy regimens. Treatment should be tailored according to that used in standard management of the transformed histology, and surgical resection is the mainstay of therapy.

publication date

  • January 1998

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 9400455

Additional Document Info

start page

  • 133

end page

  • 8

volume

  • 159

number

  • 1