Gramicidin channel kinetics under tension Academic Article uri icon

Overview

MeSH Major

  • Gramicidin
  • Ion Channels
  • Lipid Bilayers
  • Models, Biological

abstract

  • We have measured the effect of tension on dimerization kinetics of the channel-forming peptide gramicidin A. By aspirating large unilamellar vesicles into a micropipette electrode, we are able to simultaneously monitor membrane tension and electrical activity. We find that the dimer formation rate increases by a factor of 5 as tension ranges from 0 to 4 dyn/cm. The dimer lifetime also increases with tension. This behavior is well described by a phenomenological model of membrane elasticity in which tension modulates the mismatch in thickness between the gramicidin dimer and membrane.

publication date

  • January 1998

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC1299385

PubMed ID

  • 9449333

Additional Document Info

start page

  • 328

end page

  • 37

volume

  • 74

number

  • 1