Radiation therapy and hydroxyurea followed by the combination of 6- Thioguanine and BCNU for the treatment of primary malignant brain tumors
Stem Cell Transplantation
This therapy was no more effective in patients with GBM than other reported series. In patients with malignant gliomas other than GBM, prolonged progression-free and overall survival is noted, without a median survival reached at the time of this report. In this subset of AG patients, survival is comparable to recent studies using halogenated prymidines during radiation and Procarbazine, CCNU, and Vincristine (PCV) as adjuvant chemotherapy.