Regulation of ceramide production and apoptosis Review uri icon

Overview

MeSH Major

  • Apoptosis
  • Ceramides

abstract

  • Ceramide is a sphingosine-based lipid signaling molecule that regulates cellular differentiation, proliferation, and apoptosis. The emerging picture suggests that coupling of ceramide to specific signaling cascades is both stimulus and cell-type specific. Ceramide action is determined within the context of other stimuli and by the subcellular topology of its production. Here, we discuss the pathways of ceramide generation and the interaction of ceramide with caspases and other apoptotic signaling cascades.

publication date

  • April 20, 1998

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1146/annurev.physiol.60.1.643

PubMed ID

  • 9558480

Additional Document Info

start page

  • 643

end page

  • 65

volume

  • 60