Clinical significance of translocation t(1;19) in childhood acute lymphoblastic leukemia in the context of contemporary therapies: A report from the children's cancer group Academic Article uri icon

Overview

MeSH Major

  • Chromosomes, Human, Pair 1
  • Chromosomes, Human, Pair 19
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Translocation, Genetic

abstract

  • The overall group of t(1;19)+ patients, as well as the subgroup with an unbalanced der(19)+ (1;19) had outcomes similar to that of t(1;19)- patients, whereas patients with balanced t(1;19) had poorer outcomes. Thus, although the overall prognostic significance of t(1;19) has been obviated by contemporary risk-adjusted protocols, the balanced t(1;19) translocation remains an adverse prognostic factor.

publication date

  • February 1998

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 9469337

Additional Document Info

start page

  • 527

end page

  • 35

volume

  • 16

number

  • 2