Mechanisms and management of acute renal allograft rejection Article Report uri icon


MeSH Major

  • HLA Antigens
  • Immunoassay
  • Isoantibodies
  • Kidney Transplantation


  • We used RT-PCR for the molecular characterization of human renal graft rejection. The studies showed that intragraft display of mRNA encoding cytotoxic attack molecule granzyme B, and immunoregulatory cytokines IL-10 or IL-2 are correlates of acute rejection, and intrarenal expression of TGF-1 mRNA, of chronic rejection. The current immunosuppressive protocol involves the use of multiple drugs, each directed at a discrete site in the T-cell activation cascade and each with distinct side effects. The immunosuppressants can be classified as inhibitors of: transcription (CsA, tacrolimus); nucleotide synthesis (azathioprine, mycophenolate mofetil, and mizoribine); growth factor signal transduction (sirolimus); and differentiation (DSG). Polyclonal antibodies and monoclonal antibodies directed at cell surface proteins are quite effective as induction therapy or anti-rejection drugs.

publication date

  • March 26, 1998



  • Report


Digital Object Identifier (DOI)

  • 10.1016/S0039-6109(05)70636-8

PubMed ID

  • 9531937

Additional Document Info

start page

  • 77

end page

  • 94


  • 78


  • 1