A new method of MR-guided mamma biopsy
Cell Transformation, Viral
Receptors, Cell Surface
Purpose: With a recently installed new open MR tomograph (Signa SP®, General Electric MS) it is possible for the first time to examine patients with obscure lesions of the mamma by MR imaging in a sitting position, similar to mammography. Method: The newly developed positioning device with intregrated surface coil permits in combination with the vertical gap in the new magnet and imaging of the mamma with a 'real time' sequence a biopsy procedure within a short time and in a manner that is acceptable for the patient. By means of an integrated interactive scan plane guiding system ('flash point tracking system') and special MR-compatible needles and wires tissue samples can be taken, or marking by a wire can be carried out within a short time. Results: Phantom experiments and first in vivo experience (10 patients) show that by means of the new mamma fixation and biopsy device a MRI of one breast in a sitting position for detecting an enhancing lesion and a MR-guided biopsy of this lesion is possible. The whole procedure takes about 25-35 minutes, comparable to the conventional stereotactic method. Conclusion. Direct patient access and the interactive guided biopsy allow in future both new diagnostic information (histological results after biopsy or after wire-guided open biopsy of a lesion only visible in MR) and the development of minimal invasive therapeutic procedures, e.g. MR-guided and - controlled interstitial thermotherapy.