Stat3 activation is required for cellular transformation by v-src Academic Article uri icon

Overview

MeSH Major

  • Cell Transformation, Neoplastic
  • DNA-Binding Proteins
  • Oncogene Protein pp60(v-src)
  • Trans-Activators

abstract

  • Stat3 activation has been associated with cytokine-induced proliferation, anti-apoptosis, and transformation. Constitutively activated Stat3 has been found in many human tumors as well as v-abl- and v-src-transformed cell lines. Because of these correlations, we examined directly the relationship of activated Stat3 to cellular transformation and found that wild-type Stat3 enhances the transforming potential of v-src while three dominant negative Stat3 mutants inhibit v-src transformation. Stat3 wild-type or mutant proteins did not affect v-ras transformation. We conclude that Stat3 has a necessary role in v-src transformation.

publication date

  • January 1998

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC110635

PubMed ID

  • 9566875

Additional Document Info

start page

  • 2553

end page

  • 8

volume

  • 18

number

  • 5