Pregnancy loss and antiphospholipid antibodies Review uri icon

Overview

MeSH Major

  • Abortion, Habitual
  • Antibodies, Antiphospholipid
  • Antiphospholipid Syndrome
  • Autoimmune Diseases
  • Pregnancy Complications

abstract

  • With the use of low-dose heparin, fetal survival of aPL pregnancies is 70-80%, but prematurity and intrauterine growth restriction are common. It is likely, but not proven, that dysregulated placental coagulation and resultant vasculopathy are the cause of fetal loss. Details of dysregulated coagulation remain to be described. Opportunities remain to determine the role of coagulopathy in repeated pregnancy loss, identify a critical event or window to which intervention might be directed, identify maternal (and fetal) characteristics other than aPL that determine fetal loss, describe toxicity profiles of current treatments, develop more specific, less toxic therapies, and describe long-term fetal and maternal outcomes.

publication date

  • November 4, 1998

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 9814680

Additional Document Info

start page

  • S86

end page

  • 9

volume

  • 7

number

  • SUPPL. 2