The treatment of chronic depression, Part 1: Study design and rationale for evaluating the comparative efficacy of sertraline and imipramine as acute, crossover, continuation, and maintenance phase therapies Academic Article uri icon

Overview

MeSH Major

  • Antidepressive Agents, Tricyclic
  • Depressive Disorder
  • Imipramine
  • Serotonin Uptake Inhibitors
  • Sertraline

abstract

  • Multiphase protocols for chronic depression can test efficacy by randomized contrasts as well as shed light on key clinical issues such as the degree of response or attrition expected at particular times in a trial or the preferred medication sequence in a potential multistep treatment program.

publication date

  • November 1998

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 9862605

Additional Document Info

start page

  • 589

end page

  • 97

volume

  • 59

number

  • 11