Radioimmunotherapy with alpha-emitting nuclides Article Report uri icon

Overview

MeSH Major

  • Neoplasms
  • Radiotherapy, High-Energy

abstract

  • This review discusses the application of alpha particle-emitting radionuclides in targeted radioimmunotherapy. It will outline the production and chemistry of astatine-211, bismuth-212, lead-212, actinium-225, bismuth-213, fermium-255, radium-223 and terbium-149, which at present are the most promising alpha-emitting isotopes available for human clinical use. The selective cytotoxicity offered by alpha particle-emitting radioimmunoconstructs is due to the high linear energy transfer and short particle path length of these radionuclides. Based upon the pharmacokinetics of alpha particle-emitting radioimmunoconstructs, both stochastic and conventional dosimetric methodology is discussed, as is the preclinical and initial clinical use of these radionuclides conjugated to monoclonal antibodies for the treatment of human neoplasia.

publication date

  • October 12, 1998

Research

keywords

  • Report

Identity

Digital Object Identifier (DOI)

  • 10.1007/s002590050306

PubMed ID

  • 9724387

Additional Document Info

start page

  • 1341

end page

  • 51

volume

  • 25

number

  • 9