Phosphoinositide kinases Review uri icon

Overview

MeSH Major

  • 1-Phosphatidylinositol 4-Kinase
  • Phosphatidylinositol 3-Kinases
  • Phosphatidylinositols

abstract

  • Phosphatidylinositol, a component of eukaryotic cell membranes, is unique among phospholipids in that its head group can be phosphorylated at multiple free hydroxyls. Several phosphorylated derivatives of phosphatidylinositol, collectively termed phosphoinositides, have been identified in eukaryotic cells from yeast to mammals. Phosphoinositides are involved in the regulation of diverse cellular processes, including proliferation, survival, cytoskeletal organization, vesicle trafficking, glucose transport, and platelet function. The enzymes that phosphorylate phosphatidylinositol and its derivatives are termed phosphoinositide kinases. Recent advances have challenged previous hypotheses about the substrate selectivity of different phosphoinositide kinase families. Here we re-examine the pathways of phosphoinositide synthesis and the enzymes involved.

publication date

  • September 15, 1998

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1146/annurev.biochem.67.1.481

PubMed ID

  • 9759495

Additional Document Info

start page

  • 481

end page

  • 507

volume

  • 67