Reduced growth of dermal fibroblasts from chronic venous ulcers can be stimulated with growth factors Academic Article Article uri icon


MeSH Major

  • Carotid Artery, Internal
  • Carotid Stenosis
  • Endarterectomy, Carotid


  • Our data demonstrate that wound-fb proliferate at a slower rate and are morphologically distinct from normal-fb. These characteristics are typical of aged or senescent cells. This decreased growth can be stimulated by growth factors basic fibroblast growth factor, epidermal growth factor, and interleukin-1 beta. Slowed growth may be partially responsible for the defect in healing of venous stasis ulcers. Furthermore, we believe that in some patients ulcer healing may be improved by exogenous provision of specific growth factors.

publication date

  • December 1997



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/S0741-5214(97)70012-0

PubMed ID

  • 9423715

Additional Document Info

start page

  • 994

end page

  • 9; discussion 999-1001


  • 26


  • 6