Soluble factor of transformed B lymphocytes in patients with HIV infection stimulates monocytes to produce PGE2 Academic Article Article uri icon

Overview

MeSH Major

  • Asthma

abstract

  • Prostaglandins of the E series (PGE) were measured in the culture supernatants of peripheral blood mono-nuclear cells (PBMC) obtained from patients with human immunodeficiency virus (HIV) infection. Cell culture supernatants from 6 patients with acquired immunodeficiency disease (AIDS) and 11 patients with AIDS-related complex contained significantly higher concentrations of PGE than those from a group of 6 healthy HIV-negative male homosexual control subjects. The PGE producer cells were among the population of plastic-adherent PBMC. Transformed B lymphocyte cell lines spontaneously derived from the blood of patients with AIDS secrete a factor that stimulates normal donor adherent PBMC to produce PGE. The HIV permissive H9 cell line stimulated a significantly lower level of PGE production, which was not associated with HIV infection.

publication date

  • March 1997

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1006/clin.1996.4321

PubMed ID

  • 9073555

Additional Document Info

start page

  • 303

end page

  • 5

volume

  • 82

number

  • 3