Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans Academic Article Article uri icon

Overview

MeSH Major

  • Education, Medical
  • Education, Medical, Continuing
  • Specialization
  • Vascular Diseases

abstract

  • This double-blinded, placebo-controlled study demonstrates that dietary supplementation with L-arginine can modestly attenuate the increased platelet reactivity seen in hypercholesterolemic patients. The data are consistent with our previous studies in hypercholesterolemic animals, demonstrating that L-arginine restores endogenous nitric oxide activity and inhibits platelet aggregation. Enhancement of endogenous nitric oxide activity is a potential novel therapeutic strategy worthy of further study.

publication date

  • March 1997

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0735-1097(97)00523-8

PubMed ID

  • 9060881

Additional Document Info

start page

  • 479

end page

  • 85

volume

  • 29

number

  • 3