Value of molecular monitoring during the treatment of chronic myeloid leukemia: A Cancer and Leukemia Group B study Academic Article uri icon

Overview

MeSH Major

  • Gene Rearrangement
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Protein-Tyrosine Kinases
  • Proto-Oncogene Proteins

abstract

  • Quantitative Southern blot analysis of blood samples may be substituted for bone marrow to monitor the response to therapy in CML and results in the need for fewer bone marrow examinations. To avoid overestimating the degree of response, marrow cytogenetic analysis should be performed when patients achieve a complete response by Southern blot monitoring. This approach provides a rational, cost-effective strategy to monitor the effect of treatment of individual patients, as well as to analyze large clinical trials in CML.

publication date

  • January 1997

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8996121

Additional Document Info

start page

  • 26

end page

  • 36

volume

  • 15

number

  • 1