Physiological tremor analysis of patients with anti-myelin-associated glycoprotein associated neuropathy and tremor Academic Article Article uri icon


MeSH Major

  • Antibodies, Anti-Idiotypic
  • Gangliosides
  • Immunoglobulin M
  • Myelin-Associated Glycoprotein


  • Tremor is often associated with anti-myelin-associated glycoprotein (anti-MAG) peripheral neuropathy (PN), but its physiology has never been accurately described. This study quantified the physiological characteristics of tremors in patients with anti-MAG demyelinating PN. Eighteen patients with tremor and PN with demyelinating features (ages 30-86, mean = 66.5 years) were evaluated for anti-MAG antibodies (positive considered > or = 1:3200) and for tremor amplitude, frequency, side-to-side relationships, and electromyographic (EMG) activation patterns. Thirteen patients had anti-MAG titers >1:3200 and 8 had both positive anti-MAG titers and tremors. Anti-MAG PN patients revealed tremors higher in amplitude, lower in frequency, with greater side-to-side amplitude ratios, greater amplitude variability, and more consistent cocontracting antagonist EMG patterns that do not attenuate with inertial loading. We conclude that anti-MAG PN tremor is not due only to exaggerated physiologic mechanisms but may reflect a distinctive form of neurogenic tremor.

publication date

  • January 11, 1997



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/(SICI)1097-4598(199701)20:1<38::AID-MUS5>3.0.CO;2-I

PubMed ID

  • 8995581

Additional Document Info

start page

  • 38

end page

  • 44


  • 20


  • 1