Signalling through the lipid products of phosphoinositide-3-OH kinase Review uri icon

Overview

MeSH Major

  • Calcium-Binding Proteins
  • Membrane Lipids
  • Phosphatidylinositols
  • Phosphoproteins
  • Phosphotransferases (Alcohol Group Acceptor)
  • Second Messenger Systems

abstract

  • When a stimulatory agonist molecule binds at the exterior of the cell membrane, a second messenger transduces the signal to the interior of the cell. Second messengers can be derived from phospholipids in the membrane by the action of the enzymes phospholipase C or phosphoinositide-3-OH kinase (PI(3)K). PI(3)K is a key player in many cellular responses, including the movement of organelle membranes, shape alteration through rearrangement of cytoskeletal actin, transformation and chemotaxis. But how PI(3)K mediates these responses is only now becoming clear.

publication date

  • July 9, 1997

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/42648

PubMed ID

  • 9192891

Additional Document Info

start page

  • 673

end page

  • 6

volume

  • 387

number

  • 6634