Adhesion molecules and rejection of renal allografts Review uri icon

Overview

MeSH Major

  • Cell Adhesion Molecules
  • Graft Rejection
  • Kidney Transplantation

abstract

  • Despite an increasing amount of immunohistochemical and molecular biology data relating to the pathogenesis of kidney transplant rejection, the pathological diagnosis of this condition still rests on routine light microscopy. The detection of changes in expression and distribution of adhesion molecules in renal allograft biopsies may open a new era of increased accuracy of rejection diagnosis. Of the various adhesion molecule reactivities, peritubular capillary VCAM-1 staining appears to be the most specific finding for chronic rejection. This same staining reaction is seen in acute rejection, but may have less specificity in that setting.

publication date

  • June 19, 1997

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 9150461

Additional Document Info

start page

  • 1476

end page

  • 80

volume

  • 51

number

  • 5