Lack of ability of ciprofloxacin-rifampin prophylaxis to decrease infection-related morbidity in neutropenic patients given cytotoxic therapy and peripheral blood stem cell transplants Academic Article uri icon


MeSH Major

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antineoplastic Combined Chemotherapy Protocols
  • Ciprofloxacin
  • Drug Therapy, Combination
  • Gram-Positive Bacterial Infections
  • Hematopoietic Stem Cell Transplantation
  • Neoplasms
  • Neutropenia
  • Rifampin


  • We compared ciprofloxacin alone with ciprofloxacin plus rifampin (C + R) as a prophylactic antibacterial regimen for 40 patients with solid tumors treated with high-dose chemotherapy and autologous stem cell transplantation support. No differences were found between groups in the time elapsed to the onset of fever, incidence of febrile episodes, amphotericin B use, and length of hospital stay. However, C + R combination prophylaxis significantly reduced the incidence of gram-positive bacteremia (five versus zero episodes) but was associated with a higher incidence of drug-related side effects.

publication date

  • January 1997



  • Academic Article



  • eng

PubMed Central ID

  • PMC163876

PubMed ID

  • 9145895

Additional Document Info

start page

  • 1175

end page

  • 7


  • 41


  • 5