Prevention of acute emesis in cancer patients following high-dose cisplatin with the combination of oral dolasetron and dexamethasone Academic Article uri icon

Overview

MeSH Major

  • Antiemetics
  • Antineoplastic Agents
  • Cisplatin
  • Dexamethasone
  • Indoles
  • Quinolizines
  • Vomiting

abstract

  • The combination of oral dolasetron 200 mg and dexamethasone 20 mg given only once prevented acute emesis in 76% of patients who received cisplatin > or = 70 mg/m2. Administration of a second dose of the regimen did not improve the observed prevention rate or delay the time to emesis. This one-dose oral regimen has comparable or better effectiveness than reported results of intravenous combination regimens in preventing cisplatin-induced vomiting and merits further study and use.

publication date

  • May 1997

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 9164228

Additional Document Info

start page

  • 2135

end page

  • 8

volume

  • 15

number

  • 5