A member of the frizzled protein family mediating axis induction by Wnt- 5A Academic Article Article uri icon


MeSH Major

  • Science


  • In Xenopus laevis embryos, the Wingless/Wnt-1 subclass of Wnt molecules induces axis duplication, whereas the Wnt-5A subclass does not. This difference could be explained by distinct signal transduction pathways or by a lack of one or more Wnt-5A receptors during axis formation. Wnt-5A induced axis duplication and an ectopic Spemann organizer in the presence of hFz5, a member of the Frizzled family of seven-transmembrane receptors. Wnt-5A/hFz5 signaling was antagonized by glycogen synthase kinase-3 and by the amino-terminal ectodomain of hFz5. These results identify hFz5 as a receptor for Wnt-5A.

publication date

  • March 14, 1997



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1126/science.275.5306.1652

PubMed ID

  • 9054360

Additional Document Info

start page

  • 1652

end page

  • 4


  • 275


  • 5306