In vivo hyperexpression of transforming growth factor-β1 in mice: Stimulation by cyclosporine Academic Article Article uri icon

Overview

MeSH Major

  • Stomach Neoplasms

abstract

  • Our observations, together, advance the hypothesis that CsA might function in vivo as an immunosuppressant not only by inhibiting the expression of proinflammatory cytokines (e.g., interleukin 2), but also by stimulating the expression of TGF-beta1, a potent immunosuppressive cytokine. Moreover, prevention of TGF-beta1 hyperexpression might prevent CsA-associated renal fibrosis, as TGF-beta1 is a fibrogenic cytokine.

publication date

  • April 15, 1997

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1097/00007890-199704150-00026

PubMed ID

  • 9112364

Additional Document Info

start page

  • 1037

end page

  • 9

volume

  • 63

number

  • 7