Recommendations for follow-up care of individuals with an inherited predisposition to cancer: II. BRCA1 and BRCA2 Conference Paper uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Genes, BRCA1
  • Mutation
  • Neoplasm Proteins
  • Ovarian Neoplasms
  • Transcription Factors

abstract

  • Efficacy of cancer surveillance or other measures to reduce risk in individuals who carry cancer-predisposing mutations is unknown. Based on expert opinion concerning presumptive benefit, early breast cancer and ovarian cancer screening are recommended for individuals with BRCA1 mutations and early breast cancer screening for those with BRCA2 mutations. No recommendation is made for or against prophylactic surgery (eg, mastectomy, oophorectomy); these surgeries are an option for mutation carriers, but evidence of benefit is lacking, and case reports have documented the occurrence of cancer following prophylactic surgery. It is recommended that individuals considering genetic testing be counseled regarding the unknown efficacy of measures to reduce risk and that care for individuals with cancer-predisposing mutations be provided whenever possible within the context of research protocols designed to evaluate clinical outcomes.

publication date

  • March 26, 1997

Research

keywords

  • Conference Paper

Identity

Language

  • eng

PubMed ID

  • 9091675

Additional Document Info

start page

  • 997

end page

  • 1003

volume

  • 277

number

  • 12