The effect of nutritional intervention on immune functions and other biomarkers in high cancer risk individuals
Forty-five healthy individuals were enrolled in a 12 week isocaloric nutritional interventional program with 20% of calories from fat and 35 grams fiber content. All had a family history of cancer as a factor motivating participation. Thirty-five individuals completed the 12 week program; of these 22 subjects had a self-reported compliance rate of 50% or more. Serum cholesterol, bile acids, estradiol, testosterone levels were unchanged, as were urinary estrogen metabolite ratios. However, there was a significant decrease in CD8 T-cells and a concomitant rise in CD4/CD8 ratio. No such changes were seen in the less than 50% compliant group. The family history of cancer was not as strong a motivating factor as we anticipated. Compliance remains a key item in carrying out nutritional intervention programs.