Gradient, high-resolution, magic-angle spinning nuclear magnetic resonance spectroscopy of human adipocyte tissue Academic Article Article uri icon

Overview

MeSH Major

  • Head and Neck Neoplasms
  • Neoplasm Staging
  • Nomograms
  • Sarcoma

abstract

  • The recently developed technique of gradient, high-resolution magic-angle spinning NMR (g-hr-MAS-NMR) spectroscopy was applied to the study of ex vivo human lipoma and liposarcoma tissue. Compared with conventional 1H-NMR, the g-hr-MAS method yielded a large improvement in spectral resolution and permitted the detection of metabolite resonance's in a well-differentiated liposarcoma that was not observed in spectra of similar samples obtained using nonspinning NMR methods. These findings suggest that g-hr-MAS-NMR spectroscopy provides a key improvement in spectral quality for ex vivo lipoma and liposarcoma tissue thereby permitting a more precise determination of tissue metabolite composition than conventional nonspinning NMR methods.

publication date

  • September 1997

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/mrm.1910380307

PubMed ID

  • 9339440

Additional Document Info

start page

  • 399

end page

  • 403

volume

  • 38

number

  • 3