MHC class I and II expression in prostate carcinoma and modulation by interferon-alpha and -gamma Academic Article uri icon

Overview

MeSH Major

  • Cullin Proteins
  • Infertility, Male
  • Intracellular Signaling Peptides and Proteins
  • Spermatogenesis
  • Spermatozoa
  • Ubiquitin-Protein Ligases

abstract

  • The present findings, taken together with previous studies, are most consistent with the expression of neoantigens by PCa, which are recognized and appropriately eliminated by the cellular immune system. This selective pressure favors outgrowth of cells which down-regulate or lose class I and/or class II expression. Understanding PCa immunobiology will help in the development of effective immunotherapy for this disease.

publication date

  • December 1997

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/(SICI)1097-0045(19971201)33:4<233::AID-PROS2>3.0.CO;2-I

Additional Document Info

start page

  • 233

end page

  • 9

volume

  • 33

number

  • 4