MHC class I and II expression in prostate carcinoma and modulation by interferon-alpha and -gamma
Intracellular Signaling Peptides and Proteins
The present findings, taken together with previous studies, are most consistent with the expression of neoantigens by PCa, which are recognized and appropriately eliminated by the cellular immune system. This selective pressure favors outgrowth of cells which down-regulate or lose class I and/or class II expression. Understanding PCa immunobiology will help in the development of effective immunotherapy for this disease.